BISTABILITY PRESERVING MODEL REDUCTION IN APOPTOSIS

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Bistability preserving model reduction in apoptosis

Biological systems are typically very complex and need to be reduced before they are amenable to a thorough analysis. Also, they often possess functionally important dynamic features like bistability. In model reduction, it is sometimes more desirable to preserve the dynamic features only than to recover a good quantitative approximation. We present an approach to reduce the order of a bistable...

متن کامل

Structure-Preserving Model Reduction

A general framework for structure-preserving model reduction by Krylov subspace projection methods is developed. The goal is to preserve any substructures of importance in the matrices L, G, C, B that define the model prescribed by transfer function H(s) = L∗(G+sC)−1B. Many existing structure-preserving model-order reduction methods for linear and second-order dynamical systems can be derived u...

متن کامل

Bistability in Apoptosis by Receptor Clustering

Apoptosis is a highly regulated cell death mechanism involved in many physiological processes. A key component of extrinsically activated apoptosis is the death receptor Fas which, on binding to its cognate ligand FasL, oligomerize to form the death-inducing signaling complex. Motivated by recent experimental data, we propose a mathematical model of death ligand-receptor dynamics where FasL act...

متن کامل

Passivity-preserving model reduction by analytic interpolation

Antoulas and Sorensen have recently proposed a passivity-preserving model-reduction method of linear systems based on Krylov projections. The idea is to approximate a positive-real rational transfer function with one of lower degree. The method is based on an observation by Antoulas (in the single-input/singleoutput case) that if the approximant is preserving a subset of the spectral zeros and ...

متن کامل

Comparison of Passivity Preserving Model Reduction Methods

Model-order reduction has become increasingly important during the past decade. As the size of very large scale integration (VLSI) circuits shrinks, while the operating frequencies and integration densities increase, the correct simulation of interconnects between transistors has become a must. Chip interconnects are described by large linear RLC networks, which are often difficult to simulate ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: IFAC Proceedings Volumes

سال: 2007

ISSN: 1474-6670

DOI: 10.3182/20070604-3-mx-2914.00072